|
Symbol Name ID |
Smad3
SMAD family member 3 MGI:1201674 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Lymphadenopathy |
Hepatosplenomegaly |
Eosinophilic infiltration of the esophagus |
Peritoneal abscess |
| Disease(s) Associated with SMAD3 | ||||
| Loeys-Dietz syndrome 3 | ||||
| pancreatic cancer |
| Mouse Phenotypes | immune system phenotype |
decreased B cell apoptosis |
impaired neutrophil chemotaxis |
abnormal B cell proliferation |
abnormal T cell proliferation |
colitis |
small intestinal inflammation |
stomach inflammation |
thymus hypoplasia |
abnormal thymus involution |
pancreas inflammation |
abnormal CD4-positive T cell differentiation |
increased neutrophil cell number |
increased monocyte cell number |
increased leukocyte cell number |
small spleen |
spleen hypoplasia |
abnormal leukocyte physiology |
abnormal T cell physiology |
abnormal T cell activation |
abnormal circulating interleukin-6 level |
abnormal immune system morphology |
enlarged mesenteric lymph nodes |
enlarged lymph nodes |
abnormal cytokine secretion |
decreased interleukin-6 secretion |
increased inflammatory response |
osteoarthritis |
tubulointerstitial nephritis |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||
| Smad3tm1Cxd/Smad3tm1Cxd | ||||||||||||||||||||||||||||||
| Smad3tm1Par/Smad3tm1Par | ||||||||||||||||||||||||||||||
| Smad3tm1Xfw/Smad3tm1Xfw | * | |||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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